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European Heart Journal 1991 12(Supplement D):105-107; doi:10.1093/eurheartj/12.suppl_D.105
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Nifedipine affects neutrophil functions by a non-calcium-mediated mechanism

K. Nalini*, K. Andrabi, N.K. Ganguly and P.L. Wahi*,

* Departments of Cardiology Chandigarh 160012, India
Experimental Medicine, Postgraduate Institue of Medical Education and Research Chandigarh 160012, India

Correspondence: Dr P.L. Wahi, Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

Cardiac disorders are known to be associated with neutrophil infiltration. The central role of calcium in modulating neutrophil functions prompted us to examine whether Ca2+ channel blockers could affect vital neutrophil functions in mice. In Vitro exposure of mice neutrophil to nifedipine resulted in inhibition of superoxide production in a dose-dependent manner. However, the inhibition of calcium uptake elicited by nifedipine did not appear to account for the observed effect since the extracellular Ca2+ enrichment and depletion did not produce a significant reversal of inhibition. In addition, there was significant inhibition (P<0·01) of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase activity. Cytosolic-free Ca2+, as measured by Quin-2AM fluorescence, showed no significant change indicating that the effect was independent of inhibition of Ca2+ influx. The hypothesis was substantiated by loss of neutrophilic functions following long-term administration of nifedipine. Our data indicate that nifedipine impairs neutrophil functions and support the hypothesis that Ca2+ antagonists also affect cellular functions by non Ca2+ mediated processes.

Key Words: Neutrophil • calcium • nifedipine • superoxide


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