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European Heart Journal 1991 12(Supplement D):113-116; doi:10.1093/eurheartj/12.suppl_D.113
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Elution of autoantibodies from the hearts of Coxsackievirus-infected mice

D. A. Neumann, J. R. Lane, A. LaFond-Walker, G. S. Allen, C. Frondoza, A. Herskowitz and N. R. Rose

The Johns Hopkins University, School of Hygiene and Public Health, Department of Immunology and Infectious Diseases Baltimore, Maryland 21205, U.S.A.

Address for correspondence: Dr David A. Neumann, The Johns Hopkins University, School of Hygiene and Public Health, Department of Immunology and Infectious Diseases, Baltimore, Maryland 21205, U.S.A.

Circulating heart-reactive antibodies are commonly reported in myocarditis and cardiomyopathy patients. While these observations support the hypothesis that autoimmune mechanisms may be involved in pathogenesis, such evidence is largely circumstantial. The current studies demonstrate that heart-reactive antibodies can be eluted from the hearts of Coxsackievirus B3-infected A/J mice with post-infectious autoimmune myocarditis, but not from the hearts of infected B10.A mice which are resistant to autoimmune myocarditis. The eluted antibodies recognize fewer cardiac antigens than are recognized by circulating antibodies. These results provide an opportunity to examine the role of autoantibodies in the pathogenesis of chronic myocarditis.

Key Words: Myocarditis • heart autoantibodies • Coxsackievirus


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