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European Heart Journal 1991 12(Supplement D):117-120; doi:10.1093/eurheartj/12.suppl_D.117
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity

N. Neu, R. Klieber*,{dagger}, M. Frühwirth and P. Berger

Institute for General and Experimental Pathology Austria
* Department of Gynecology and Obstetrics, Medical School, University of Innsbruck Austria
{dagger} Immunoendocrinology Research Unit of the Austrian Academy of Sciences Innsbruck, Austria

Address for correspondence: Dr Nikolaus Neu, Institute for General and Experimental Pathology, Fritz-Pregl-Strasse 3, 6020 Innsbruck, Austria

Immunization with purified cardiac myosin induces autoimmune myocarditis in A strain mice. Because this disease parallels Coxsackievirus B3 (CB3)-induced myocarditis in many respects, we are now using the immunization model as a virus-free system to study certain forms of immunologically-mediated heart disease. In the present article we will describe several characteristics of the humoral and cellular autoimmune response acting in myosin-induced myocarditis. Furthermore, we discuss hypotheses which might explain how myosin-reactive T cells recognize and attack the heart tissue.

Key Words: Autoimmune myocarditis • myosin autoantibodies • cellular immune reactions • MHC antigen expression


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