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European Heart Journal 1991 12(Supplement D):134-136; doi:10.1093/eurheartj/12.suppl_D.134
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Induction of cytokine release from human monocytes by coxsackievirus infection

A. Henke, M. Nain, A. Stelzner and D. Gemsa

Institute of Immunology, Philipps University Marburg and Division of Virology, Academy of Sciences Jena, Germany

Address for correspondence: Prof. Dr D. Gemsa, Institute of Immunology, University of Marburg, Robert-Koch-Str. 17, D-3550 Marburg, Germany

Coxsackievirus B3 (CVB3) infections produce an inflammatory and immune response that suggests the involvement of cytokines. In this in vitro study, we exposed purified human monocytes to CVB3 and determined the release of interferon (IFN), interleukin 1β (IL-1β and tumour necrosis factor-{alpha} (TNF-{alpha}). Exposure to CVB3 did not alter the viability of monocytes, however, it induced an increased adherence. After 12 and 24 h of CVB3 exposure, monocytes released large amounts of IFN, IL-1β and TNF-{alpha}. These data show that CVB3 strongly affects human monocytes and activates them to production of biologically active cytokines, particularly IL-1β and TNF-{alpha}. It is suggested that both cytokines, when released in large amounts and for a prolonged period, may contribute to a strong inflammatory response and eventual tissue damage in afflicted organs such as the myocardium.

Key Words: Monocytes • coxsackievirus B3 • cytokine release • interleukin 1 (IL-1) • tumour necrosis factor-{alpha} (TNF-{alpha}) • interferon (IFN)


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