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European Heart Journal 1991 12(Supplement D):18-21; doi:10.1093/eurheartj/12.suppl_D.18
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Progress and challenges in the pathological diagnosis of myocarditis

B. M. McManus*,, L. H. Chow*, S. J. Radio*, S. M. Tracy{dagger}, M. A. Beck{dagger}, N. M. Chapman{dagger}, K. Klingel{ddagger} and R. Kandolf{ddagger}

* Cardiovascular Registry, Department of Pathology and Microbiology, University of Nebraska Medical Center Omaha, Nebraska, U.S.A.
{dagger} Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center Omaha, Nebraska, U.S.A.
{ddagger} Enterovirus Research Group, Max Planck Institute for Biochemistry Martinsried, Germany

Address for correspondence: Bruce M. McManus, MD, PhD, Cardiovascular Registry. Department of Pathology and Microbiology. 600 South 42nd Street, Omaha, NE 68198-3135, U.S.A.

The pathological diagnosis of myocarditis rests on well-described histopathological criteria. Appreciation for the disease-specific sensitivity of the endomyocardial biopsy, as well as the phenotypical and functional nature of inflammatory infiltrates, will enhance the clinical utility of the biopsy technique. New information regarding the role of enteroviruses in immunological sensitization and the study of enteroviruses in murine models and human patients are fostering new perspectives and routes of investigation of appropriate therapeutic interventions for myocarditis.

Key Words: Pathological diagnosis • myocarditis • cardiomyopathy • enterovirus • murine model • immunohistochemistry • cytolytic assays


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