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European Heart Journal 1991 12(Supplement D):36-38; doi:10.1093/eurheartj/12.suppl_D.36
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Impaired myocyte function in vitro incubated with sera from patients with myocarditis

L. Drude*, F. Wiemers and B. Maich{dagger}

Philipps University, Department of Internal Medicine Cardiology, Marburg, Germany

Correspondence: Ludwig Drude, MD, Philipps University, Department of Internal Medicine, Cardiology, Baldinger Strasse, D-3550 Marburg, Germany

Sera positive for antimyolemmal antibodies (AMLAs) from patients with acute biopsy-proven myocarditis exerted a cytotoxic effect on cardiocytes stimulated in vitro. Using an edge-detecting system, contraction amplitude and contraction velocity were altered after the addition of AMLA-positive sera when compared to sera from healthy controls. Antibodies alone did not change the functional parameters. Only the presence of complement and heart-reactive antibodies mediated the detrimental effects. This suggests that a complement-mediated antibody-dependent immune mechanism is operative in human myocarditis.

Key Words: Myocyte • contraction • rat • myocarditis

* Supported by a grant from the Kempkes Stiftung, Marburg (Grant 14/89).

{dagger} Supported by a grant from the Deutsche Forschungsgemeinschaft (Ma 780/6).


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