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European Heart Journal 1991 12(Supplement D):39-43; doi:10.1093/eurheartj/12.suppl_D.39
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Effect of dexamethasone on coxsackievirus B2-infected rat beating heart cells in culture

Y. Z. Yang*,{dagger},, W. L. Yuan*, Q. Guo{dagger}, Z. X. Gong{ddagger}, T. S. Zhow§, J. Y. Shen{ddagger} and H. Z. Chen*

* Department of Cardiology Shanghai 200031, P.R.C.
{dagger} Virology Unit, Shanghai Institute of Cardiovascular Diseases, Zhong Shan Hospital, Shanghai Medical University Shanghai 200032, P.R.C.
{ddagger} Virology Unit, Shanghai Institute of Biochemistry, Chinese Academy of Sciences Shanghai 200031, P.R.C.
§ Shanghai Institute of Physiology, Chinese Academy of Sciences Shanghai 200031, P.R.C.

Addrees for correspondence: Prof. Dr Ying-Zhen Yang, Virology Unit. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases. Zhongshan Hospital, Shanghai Medical University. 136, Yi Xue Yuan Road, Shanghai 200032, P.R.C. This study was supported by grants from Chinese Ministry of Education and Shanghai Science Committee

The effects of dexamethasone on cultured rat beating heart cells experimentally infected with coxsackievirus B2 were investigated at an early stage (1–3 days) post challenge. Changes in the release of the cardiac enzyme, aspartate amino-transferase (AST), beating %, cytopathic effect (CPE), virus titre, ultrastructure and alterations of the electrical activity were evaluated. The protective effects of dexamethasone on infected cells were abolished except the release of AST at 5 days post infection.

These results suggest that steroids may benefit patients with severe myocarditis if conventional therapy for protection of the myocardium and modulation of immunologic function are concomitantly given.

Key Words: Dexamethasone • heart cell culture • coxsackievirus B2 • myocarditis • viral cytopathogenic effect • aspartate amino-transferase • electron microscopy • electrical parameter


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