Skip Navigation

European Heart Journal 1991 12(Supplement D):56-59; doi:10.1093/eurheartj/12.suppl_D.56
Copyright © 1991 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Archard, L. C.
Right arrow Articles by Richardson, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Archard, L. C.
Right arrow Articles by Richardson, P. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 The European Society of Cardiology

Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value

L. C. Archard*,, N. E. Bowles*, L. Cunningham*, C. A. Freeke*, E. G. J. Olsen{dagger}, M. L. Rose{ddagger}, B. Meany§, H. J. F. Why§ and P. J. Richardson§

* Biochemistry Department, Charing Cross and Westminster Medical School London, UK
{dagger} Histology Department, Brompton and National Heart Hospital London, UK
{ddagger} Immunology Department, Harefield Hospital Uxbridge, Middlesex, UK
§ Cardiac Department, King's College Hospital London, U.K.

Address for correspondence: L C. Archard, Biochemistry Department, Charing Cross and Westminster Medical School, London, UK

Enteroviruses are well recognized in the aetiology of myocarditis. Molecular hybridization using enterovirus group-specific probes shows that virus can be detected in endomyocardial biopsies and persists in myocardium after the inflammation heals. Virus persistence is associated with the subsequent development of dilated cardiomyopathy, progressing to end-stage disease requiring cardiac transplantation.

Infectious virus cannot usually be isolated from myocardium nor can virus-specific antigens be detected after the initial inflammatory stage. Patients with healed myocarditis or dilated cardiomyopathy may have no histological evidence of inflammation despite detection of virus-specific RNA sequences by molecular hybridization.

Persisting enterovirus RNA in dilated cardiomyopathy is the strongest known predictor of poor prognosis. The molecular mechanism of virus persistence is the selection of defective virus mutants during the initial phase of disease.

Key Words: Enterovirus • myocarditis • dilated cardiomyopathy • molecular probes • prognosis • persistence


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
R. S. Fujinami, M. G. von Herrath, U. Christen, and J. L. Whitton
Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease
Clin. Microbiol. Rev., January 1, 2006; 19(1): 80 - 94.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
U. Kuhl, M. Pauschinger, P. L. Schwimmbeck, B. Seeberg, C. Lober, M. Noutsias, W. Poller, and H.-P. Schultheiss
Interferon-{beta} Treatment Eliminates Cardiotropic Viruses and Improves Left Ventricular Function in Patients With Myocardial Persistence of Viral Genomes and Left Ventricular Dysfunction
Circulation, June 10, 2003; 107(22): 2793 - 2798.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Y Li, Z Pan, Y Ji, T Peng, L.C Archard, and H Zhang
Enterovirus replication in valvular tissue from patients with chronic rheumatic heart disease
Eur. Heart J., April 1, 2002; 23(7): 567 - 573.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Peng, T. Sadusky, Y. Li, G. R. Coulton, H. Zhang, and L. C. Archard
Altered expression of Bag-1 in Coxsackievirus B3 infected mouse heart
Cardiovasc Res, April 1, 2001; 50(1): 46 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. A. Huber
T cells expressing the {gamma}{delta} T cell receptor induce apoptosis in cardiac myocytes
Cardiovasc Res, February 1, 2000; 45(3): 579 - 587.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.