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European Heart Journal 1991 12(Supplement D):65-68; doi:10.1093/eurheartj/12.suppl_D.65
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Does CMV infection play a role in myocarditis? New aspects from in-situ hybridization

U. Schönian, M. Crombach and B. Maisch

Department of Cardiology, Philipps University of Marburg Marburg, Germany

Address for correspondence: Dr Ute Schönian, Philipps University of Marburg, Department of Internal Medicine-Cardiology, Baldinger Strasse, 3550 Marburg, Germany

Endomyocardial biopsies of 20 patients with active myocarditis, 15 with post-myocarditis and 22 with acute perimyocarditis were assayed for cytomegalovirus (CMV) DNA by in-situ hybridization with a biotinylated DNA-probe. Positive probes were found in 10% of the cases with acute myocarditis and in 7% of those with post-myocarditis; no CMV-positive patients were found in acute peri-myocarditis. The results were compared to anti-CMV antibodies from patients sera detected by ELISA technique.

Key Words: Myocarditis • cytomegalovirus • in-situ hybridization


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