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European Heart Journal 1991 12(Supplement D):69-72; doi:10.1093/eurheartj/12.suppl_D.69
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Murine cytomegalovirus myocarditis

J. E. Craighead, S. A. Huber and W. B. Martin

Department of Pathology, University of Vermont College of Medicine Burlington, Vermont, U.S.A.

Address for correspondence: J. E. Craighead, Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, U.S.A.

Murine cytomegalovirus infects a variety of organs after inoculation into adult male mice. We have established a model of myocarditis in which focal lesions form adjacent to virus-infected endothelial cells. The development of the myocarditis is mediated by CD4+ helper T cells. The lesions fail to develop when these cells are eliminated from the animal by administration of a specific monoclonal antibody. Alternatively, repletion of thymectomized, irradiated and bone-marrow reconstituted animals with CD4+ cells results in myocarditis. The evidence, although incomplete, suggests that a delayed hypersensitivity response is the pathogenetic mechanism involved.

Key Words: Cytomegalovirus • myocarditis • CD4+T lymphocytes • delayed hypersensitivity


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