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European Heart Journal 1991 12(Supplement D):95-98; doi:10.1093/eurheartj/12.suppl_D.95
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

High voltage activated calcium channels: molecular composition and function

V. Flockerzi, E. Bosse, M. Biel*, R. Hullin* and F. Hofmann*

Medizinische Biochemie, Universität des Saarlandes 6650 Homburg, Germany
* Institut für Pharmakologie und Toxikologie Technische Universität München 8000 München 40 Germany

Address for correspondence: Privatdozent Dr Veit Flockerzi, Medizinische Biochemie, Universität des Saarlandes D-6650 Homburg/Saar, Germany

Voltage-activated calcium channels comprise a group of similar yet distinct proteins or protein complexes that differ in electrophysiological properties, modulation by phosphorylation and GTP-binding proteins and in their relative sensitivity to organic calcium channel blockers. Cloning of the cDNA of L-type calcium channels from skeletal muscle, heart and smooth muscle opens the way to understanding the molecular basis of channel function and regulation and provides means of studying calcium channels in other tissues.

Key Words: Ca2+ channel • cDNA cloning • phosphorylation • expression


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