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European Heart Journal 1991 12(Supplement F):10-17; doi:10.1093/eurheartj/12.suppl_F.10
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Sodium channel blockers in the treatment of ventricular arrhythmias: different effects in the normal, ischaemic or failing heart?

W. Haverkamp, G. Hindricks, Ch. Fechtrup, M. Borggrefe and G. Breithardt

Medical Hospital of the Westfdlische Wilhelms-Universität of Münster, Department of Cardiology-Angiology Münster, Germany

Correspondence: Dr. Wilhelm Haverkamp, Medizinische Klinik und Poliklinik, Innere Medizin C (Kardiologie, Angiologie), Westfälische Wilbelms-Universität, Albert-Schweitzer StraBe 33, D-4400 Münster, Germany

In past decades, numerous experimental and clinical studies have improved our knowledge of the electrophysiological effects of sodium channel blockers, as well as of the mechanisms of arrhythmogenesis. However, the mechanisms of antiarrhythmic as well as potentially proarrhythmic drug action have been less well clarified. Sodium channel blocker agents have different effects on the normal, ischaemic, and failing heart since their antiarrhythmic actions depend on the substrate and the mechanisms of arrhythmogenesis, as well as other mostly interrelated cardiac and non-cardiac factors. Strict criteria of efficacy and safety have to be applied when sodium channel blockers are used for the treatment of ventricular arrhythmias.

Key Words: Ventricular arrhythmias • sodium channel blocker • congestive heart failure


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