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European Heart Journal 1991 12(Supplement F):145-148; doi:10.1093/eurheartj/12.suppl_F.145
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Supersensitivity to isoprenaline induced in cultured neonatal rat heart cells by certain eicosatetraenoic acids

G. Wallukat, H. Kuehn* and A. Wollenberger

Institut für Herz-Kreislauf-Forschung Berlin-Buch,Germany
* Institut für Biochemie, Humboldt-Universität zu Berlin Berlin, Germany

Correspondence: Drs G. Wallukat and A. Wollenberger, Bereich für zelluläre und molekulaie Kardiologie, Robert-Rössle-Strasse 10, 0-1115 Berlin-Buch, Germany

Among a number of racemic eicosatetraenoic acids (HETEs) investigated, 15-R/S HETE and 11-R/S-HETE were the only ones that enormously potentiated the chronotropic action of isoprenaline on neonatal rat heart myocytes in rocked culture. The effect of the 15-R/S-HETE was exclusively due to the S isomer.

Key Words: Eicosatetraenoic acids • isoprenaline • cardiomyocytes • β-adrenergic supersensitivity


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