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European Heart Journal 1991 12(Supplement F):4-9; doi:10.1093/eurheartj/12.suppl_F.4
Copyright © 1991 by the European Society of Cardiology.
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© 1991 The European Society of Cardiology

Triggered activity in the heart: cellular mechanisms of early after-depolarizations

C. T. January, V. Chau and J. C. Makielski

Cardiac Electrophysiology Laboratories, Department of Medicine (Cardiology), The University of Chicago Chicago, Illinois, USA

Correspondence: Craig T. January, MD, PhD, Department of Medicine (Cardiology), Box 322, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA.

The arrhythmogenic effects of ischaemia and reperfusion result from the complex interplay of normal ion channels reacting to the ischaemic environment, channels made abnormal by ischaemic modification, the appearance of new currents normally not present, and possible ischaemic alteration of metabolic electrogenic processes. In this report the cellular mechanisms thought to underlie the different types of triggered activity will be discussed. The role of Ca2+ channels and Ca2+ ‘window’ current in the generation of early after-depolarizations (EADs) will be elucidated.

Key Words: Ischaemia • triggered arrhythmias • early after-depolarizations • calcium current • ion channels


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