Copyright © 1992 by the European Society of Cardiology.
© 1992 The European Society of Cardiology
Increased plasminogen activator inhibitor and tissue plasminogen activator levels in subjects with electrocardiographic abnormality indicative of ischaemic heart disease: A cross-sectional study in Norsjö, Sweden
Primary Health Care Center, Norsjö, Department of Medicine, Skelleftea Hospital and Departments of Clinical Physiology, and Clinical Chemistry, Umea University Hospital Sweden
Received 20 August 1990; revised 15 November 1990; .
Correpondence Dr Torbjörn K. Nilsson, Dept. of Clinical Chemistry, University Hospital, S-90185 Umea, Sweden
Abstract
The plasma levels of tissue plasminogen activator (tPA) antigen concentration and plasminogen activator inhibitor (PAI) activity were measured in a random sample of 260 subjects, 30, 40,50, or 60 years of age. Electrocardiographic Q.ST and/ or ST-T changes, suggestive of definite or possible ischaemic heart disease (IHD), were found in 21% of the 50-year-old and 37% of the 60-year-old subjects. As compared to subjects lacking such signs, plasma tPA and PAI levels were significantly increased in the 60-year-old group, and PAI tended to be increased in the 50-year-old group. Previous case-control studies, usually performed at specialized centres and liable to sampling biases, have suggested an association between increased PAI levels and ischaemic heart disease. This cross-sectional population study provides independent data that patients with electrocardiographic signs of IHD have increased levels of both PAI and tPA antigen.
Key Words: Electrocardiography • fibrinolysis • ischaemic heart disease • plasminogen activator • tissue plasminogen activator
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