Copyright © 1992 by the European Society of Cardiology.
© 1992 The European Society of Cardiology
Regulatory peptides in the plasma of patients with chronic cardiac failure at rest and during exercise
*Royal Victoria Hospital Belfast BT126BA, Northern Ireland
Department of Medicine, The Queen's University of Belfast Belfast, Northern Ireland
Received 20 June 1991; revised 27 February 1992; .
Correspondence: D. P. Nicholls, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland
Abstract
The levels of several regulatory peptides were measured in peripheral plasma samples from individuals with chronic cardiac failure (CCF) and matched controls in both the resting state and during a short period of maximal exercise. Basal levels of noradrenaline (NA; 705±114 vs 195±54ng .l–1 mean±SEM; P<0·05), plasma renin activity (PRA; 12·9±2·9 vs 2·l±0·3ngAl ml–1.h–1; P<0·05) and aldosterone (ALDO; 325±49vs 87±8ng. l–1 P<0·05) were all raised in the patients with CCF, and increased further with exercise. Basal circulating levels of atrial natriuretic peptide (ANP) were also significantly higher in the CCF group compared to controls (136±35 vs 27±5 ng .l–1; P<0·01), but the response to exercise was attenuated, so that at peak exercise, no significant difference was observed. Basal circulating levels of gastrin-releasingpeptide (GRP) (29±4 vs 40±4ng . l–1P<0·05) andsecretin (13±1 vs 32±4ng. l–1;P<0·05) were significantly lower in the CCF group when compared to controls and there was no significant change in the levels of either peptide with exercise. Levels of neurokinin A (NKA), neuropeptide Y (NPY) and neurotensin (NT) were somewhat higher in patients, but the differences were not significant, and there were no changes during exercise. There were also no significant differences in the levels of vasoactive intestinal peptide (VIP), glucose-dependent insulinotropic polypeptide (GIP), insulin or glucagon in either experimental group both before and during exercise. We have therefore identified different circulating levels of certain regulatory peptides in patients with CCF, but the significance of these remains unclear.
Key Words: Regulatory peptides • radioimmunoassay • heart failure • exercise physiology
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