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European Heart Journal 1992 13(10):1405-1409;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Lp(a) levels in patients undergoing aorto-coronary bypass surgery

M. R. AVERNA, C. M. BARBAGALLO, S. OCELLO*, O. DORIA*, G. DAVI, V. SCAFIDI, R. ALBIERO* and A. NOTARBARTOLO

Istituto di Medicina Interna e Geriatria, Cattedra di Patologia Medica, Universita di Palermo Italy
*Divisione di Cardiochirurgia Ospedale Civico, USL 58, Palermo, Italy

Received 24 October 1991; revised 6 April 1992; .

Correspondence: Dr Carlo Maria Barbagallo, Viale Francesco Scaduto 6/C, 90144 Palermo, Italy

Abstract

The aims of this study were to evaluate plasma lipid, apoprotein and Lp(a) levels in patients with severe coronary atherosclerosis undergoing aorto-coronary bypass surgery (BP) and to relate these parameters to the involvement of one or more vessels. Seventy-seven male patients and 77 cardiovascular disease-free controls, matched for sex, age and body weight were studied. Higher triglyceride and apo B levels with lower HDL-cholesterol and apo A-I levels were found in BP patients in comparison with the controls. Lp(a) levels were slightly, but not significantly, increased. Moreover BP patients presented a significantly higher prevalence of HDL-cholesterol levels below 35 mg dl–1 (49·3% vs 22·1%) and Lp(a) levels above 70mg dl–1 (10·4% vs 1·3%) than the controls. When patients were divided according to the number of coronary vessels involved (one, two or three), no significant difference was found, with a trend to increase in Lp(a) mean levels and in prevalence of Lp (a) levels above 30 and 70 mg dl–1 in more severely diseased patients.

These results suggest that patients with severe coronary artery disease undergoing aorto-coronary bvpass surgery show low HDL-cholesterol levels with high triglyceride levels. Moreover Lp(a) levels above 70 mg dl–1 are highly associated with severe coronary vessel stenosis.

Key Words: Aorto-coronary bypass • lipids • apoproteins • Lp(a)


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