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European Heart Journal 1992 13(11):1473-1476;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Plasma calcitonin gene-related peptide decreases in chronic congestive heart failure

H. TAQUET*,, M. KOMAJDA{dagger}, O. GRENIER{dagger}, F. BELAS{dagger}, C. LANDAULT*, A. CARAYON*, P. LECHAT{dagger}, Y. GROSGOGEAT{dagger} and J. C. LEGRAND*

*Services de Biochimie Médicate, Groupe hospitalier Pitié-Salpêtrière 47–91 Bd de I'Hopital, 75013 Paris, France
{dagger}Cardiologie, Groupe hospitalier Pitié-Salpêtrière 47–91 Bd de I'Hopital, 75013 Paris, France

Received 10 January 1992; revised 5 May 1992; .

Correspondence: H. Taquet, Biochimie Médicale, CHU Pitié-Salpètriere, 91 Bd de PHopital, 75013 Paris, France

Abstract

To investigate the role of calcitonin gene-related peptide (CGRP) in cardiac failure, a sensitive and specific radioimmu-noassay was developed to study plasma levels of CGRP in 37 normal subjects and 41 patients with heart failure (HF). The mean plasma levels of CGRP were 294·3 pg . ml–1 (SEM: 41·4) in normal subjects and 121·2 pg . ml–1 (SEM: 21·2) in HF patients. The significant decrease observed in HF patients suggests that CGRP is involved in the pathogenesis of heart failure via a direct effect or via modulation of sympathetic nervous activity.

Key Words: Calcitonin gene-related peptide • catecholamines • human • congestive heart failure


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