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European Heart Journal 1992 13(11):1556-1561;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Effects of propafenone on pacing-induced ventricular fibrillation and intracellular calcium in rat hearts

T. STEFENELLI*, S. T. WU, W. W. PARMLEY and J. WIKMAN-COFFELT

Department of Medicine and Cardiovascular Research Institute San Francisco, CA, U.S.A.

Received 9 July 1992; .

Correspondence: William W. Pannley, M.D., Room M-1186. University of California San Francisco, San Francisco, CA 94143, U.S.A.

Abstract

Propafenone is an antiarrhythmic agent with fast sodium channel, calcium channel, and ß-adrenergic receptor blocking properties. The effects of propafenone on arrhythmias, free intracellular calcium and left ventricular performance were studied using perfused rat hearts during (i) pacing-induced ventricular fibrillation and (ii) infusion with 2·65x10–6 M, 5·3x10–6 M and 7·9x10–6 M propafenone hydrochloride (corresponding to approximately 1, 2 and 3 mg kg–1 body weight). A bolus of I mg kg–1 propafenone during ventricular fibrillation resulted in a decrease in intracellular calcium, with subsequent conversion to sinus rhythm. In perfused hearts with sinus rhythm propafenone produced a dose-dependent decrease in heart rate and myocardial oxygen consumption together with a rise in left ventricular diastolic pressure, and diastolic [Ca2+]), indicative of depression of left ventricular function. We conclude that a bolus of propafenone during ventricular fibrillation leads to a decrease in [Ca2+]1 preceding conversion to sinus rhythm. In rat hearts with sinus rhythm the depressive effects of propafenone on [Ca2+]l are dose dependent.

Key Words: Propafenone • ventricular fibrillation • antiarrhythmic agents • intracellular calcium


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