Copyright © 1992 by the European Society of Cardiology.
© 1992 The European Society of Cardiology
Spontaneous and inducible ventricular arrhythmias in a canine model of chronic heart failure: relation to haemodynamics and sympathoadrenergic activation
Henry Ford Heart and Vascular Institute, Division of Cardiovascular Medicine, Henry Ford Hospital 2799 West Grand Boulevard, Detroit, Michigan 48202, U.S.A.
*University of Heidelberg, Medical University Hospital, Department of Cardiology Bergheimerstr 58, D-6900 Heidelberg, Germany
Received 1 July 1992; .
Correspondence: Hani N. Sabbah, PhD, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, U.S.A.
Abstract
The relationship between the incidence, frequency and complexity of spontaneous ventricular arrhythmias and the extent of haemodynamic compromise and sympathoadrenergic hyperactivity was evaluated in a canine model of chronic heart failure produced by multiple sequential intracoronary microembolizations. Ambulatory ECG Holler monitoring recorded during chronic heart failure in 18 dogs revealed spontaneous ventricular arrhythmias ranging from single ventricular premature beats (VPBs) to non-sustained episodes of ventricular tachycardia (VT). Single VPBs were present in 94% of dogs, couplets in 67%, triplets in 28% and spontaneous episodes of non-sustained VT in 33%. Dogs with >28 VPBs .h–1 (n = 9) had a markedly higher plasma norepinephrine (PNE) concentration (1001±185 vs 561 ±31 pg.ml–1) (P<0·03), and a higher pulmonary artery wedge pressure (PAWP) (18 ±2 vs 12 ±1 mmHg) (P<0·03) than dogs with 
28 VPBs. H–1 (n = 9). Dogs that developed spontaneous episodes of VT also had significantly higher PNE levels (1119±247 pg . ml–1) compared to dogs that did not develop VT(612 ±64 pg . ml–1) (P<0·02). Programmed ventricular stimulation performed in seven of 18 dogs resulted in the development of sustained monomorphic VT in three and ventricular fibrillation in three dogs each (43%, 43%). Dogs with inducible sustained monomorphic VThada significantly higher number of ambient arrhythmias and higher PA WP compared to dogs that did not develop sustained VT. The observed complexity .frequency and incidence of spontaneous and inducible ventricular arrhythmias in this canine model are similar to those described in patients with chronic heart failure.
Key Words: Congestive heart failure • ventricular arrhythmias • catecholamines • ventricular function
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