Copyright © 1992 by the European Society of Cardiology.
© 1992 The European Society of Cardiology
On-line quantification of ventricular function during dobutamine stress echocardiography
From the Cardiovascular Division and Department of Physics, Washington University School of Medicine St Louis, Missouri, U.S.A.
Received 28 February 1992; revised 8 July 1992; .
Correspondence Julio E. Perez, MD, Cardiovascular Division, Washington University, 660 South Euclid, Box 8086, St Louis, MO 63110, U.S.A.
Abstract
To develop an approach for on-line quantification of left ventricular size and function during pharmacological stress testing we employed echocardiographic automatic edge detection via integrated backscatter imaging during dobutamine infusion in 27 patients. Ventricular cavity areas, fractional area change and rate of cavity area change were obtained on-line with instantaneous graphic display of the data. When compared to baseline image data, patients with a normal response exhibited modest (15%) reduction in end-diastolic cavity areas at peak dobutamine level, but marked (33%) reduction in systolic areas yielding a 52% increase in fractional area change (n = 13; P<0·001). The second group of patients (n = 14) had an abnormal response characterized by limited changes in measured parameters of ventricular function and reduced fractional area change (P< 0·05). On-line quantification during pharmacological stress echocardiography is a promising addition to the test for surveillance and objective instantaneous evaluation of global cardiac responses.
Key Words: Echocardiography • automatic edge detection • dobutamine stress echocardiography
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