Skip Navigation

European Heart Journal 1992 13(12):1684-1691;
Copyright © 1992 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by CHIN, J. C.
Right arrow Articles by BRUSCHKE, A. V. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CHIN, J. C.
Right arrow Articles by BRUSCHKE, A. V. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 The European Society of Cardiology

The acute effects of intravenous nisoldipine on left ventricular function within 24h after acute myocardial infarction

J. C. CHIN*, E. E. VAN DER WALL*,, V. MANGER CATS*, A. VAN DER LAARSE*, J. A. K. BLOKLAND{dagger}, E. J. K. PAUWELS{dagger} and A. V. G. BRUSCHKE*

*Departments of Cardiology University Hospital Leiden, The Netherlands
{dagger}Nuclear Medicine, University Hospital Leiden, The Netherlands

Received 13 December 1992; revised 8 July 1992; .

Correspondence E. E. van der Wall, M D. F.E.S.C., Department of Cardiology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands

Abstract

Nisoldipine is a calcium antagonist with potent coronary vasodilating effects in patients with chronic stable angina pectoris. We studied the acute effects of nisoldipine in six patients within 24 h (mean 14±4 h) after the onset of myocardial infarction. Nisoldipine was administered as a 4·5µg kg–1 intravenous bolus over 3 min followed by intravenous infusion of 0·2µg kg–1 min–1 during 60 min. Radionuclide angiography, cardiac output and intra-arterial blood pressure measurements were performed before and during nisoldipine. Left ventricular ejection fraction increased from 48·3 ±10·3% to 55·3± 11·8% (P=0·034) during nisoldipine infusion. Regional wall motion score changed during nisoldipine infusion from 3·3±2·5 to 1·8±2·6 (P=0·027). Cardiac output increased from 5·5±10 to 7·3±1·31 min–1 (P=0·0001). Heart rate increased from 78± 12 to 88 ± 11 beats. Min–1 (P=0004). Mean arterial blood pressure decreased from 91·7±20·2 to 78·7±13·1 mmHg (P=0·038). The rate-pressure product did not change significantly during nisoldipine infusion. It is concluded that nisoldipine improves global and regional left ventricular function in patients with acute myocardial infarction within the first 24h. Our findings suggest that this effect is achieved without increasing myocardial oxygen demand.

Key Words: Nisoldipine • acute myocardial infarction • left ventricular function • radionuclide angiography


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.