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European Heart Journal 1992 13(12):1718-1719;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Deletion of mitochondrial DNA in the endomyocardial biopsy sample from a patient with Kearns-Sayre syndrome

R. ANAN, M. NAKAGAWA*, I. HIGUCHI*, S. NAKAO, K. NOMOTO and H. TANAKA

*The First and Third Departments of Internal Medicine, Faculty of Medicine, Kagoshima University 8-35-1 Sakuragaoka, Kagoshima 890, Japan

Received 3 June 1992; .

Correspondence: H Tanaka, MD, The First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890, Japan

Abstract

A 15-year-old boy with Kearns-Sayre syndrome is reported. The deletion of mitochrondrial DNA in the endomyocardial biopsy sample from the patient was confirmed by the polymerase chain reaction method, and was identified to that in the skeletal muscle.

Key Words: Kearns-Sayre syndrome • mitochondrial DNA • polymerase chain reaction method • endomyocardial biopsy


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