Skip Navigation

European Heart Journal 1992 13(3):321-329;
Copyright © 1992 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by TEO, K. K.
Right arrow Articles by YACOUB, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TEO, K. K.
Right arrow Articles by YACOUB, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 The European Society of Cardiology

Preserved left ventricular function during supine exercise in patients after orthotopic cardiac transplantation

K. K. TEO*, S. YUSUF*,{dagger},{ddagger}, J. WITTES§, S. THEODOROPOULOS{dagger}, N. DHALLA{dagger}, J. AIKENHEAD{dagger} and M. YACOUB{dagger}

*Clinical Trials Branch, DECA, NHLBI Bethesda, MD, U.S.A.
{dagger}Harefield Hospital Middlesex, U.K.
§Biostatistics Research Branch, DECA, NHLBI Bethesda, MD, U.S.A.

Received 14 December 1990; revised 3 March 1991; .

{ddagger}Present address and address for correspondence: Salim Yusuf, DPhil, MRCP, Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Federal Building. Room 5C8A. Bethesda, Maryland, 20892, U.S.A.

Abstract

Cardiac denervation may affect cardiovascular responses during exercise in patients after orthotopic cardiac transplantation. In 17 such patients. haemodynamic responses and left ventricular function were examined by radionuclide ventriculography during and after supine exercise, at an average of 17.1± 2.6 months after surgery. Data were also obtained during ‘volume loading’ brought about by leg elevation before exercise. Results were compared with those of six normal controls.

At rest, heart rate was significantly faster among transplant patients than among controls (P <0.0003). No significant inter-group dfferences in changes in cardiovascular parameters were found between the two groups during leg elevation. During exercise, heart rate in transplant patients rose at a significantly slower rate than controls (P = 0.0001), but similar increases in ejection fraction, stroke volume and cardiac output were observed among transplant patients and controls. Decline in heart rate (P = 0.0001), ejection fraction (P = 0.0007) and cardiac output (P = 0.0001) was significantly slower in transplant patients during recovery.

Although there were differences in rates of increases in heart rate between transplant patients and controls during supine exercise, there were no inter-group differences in increases in cardiac output and ejection fraction and changes in haemodynamic responses and left ventricular volumes.

Key Words: Cardiac transplantation • exercise • ventricular function • haemodynamics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.