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European Heart Journal 1992 13(4):473-477;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Lack of prognostic implications of spontaneously occurring or stimulation induced atrial tachyarrhythmias in patients with dilated cardiomyopathy

B. BREMBILLA-PERROT and A. TERRIER DE LA CHAISE

Cardiology A-B, Chu of Brabois Vandoeuvre, France

Received 23 October 1990; revised 22 May 1991; .

Correspondence. Béatrice Brembilla-Perrot, Cardiologie A, Chu Brabois, 54500 vandoeuvre Les Nancy, France

Abstract

A prospective study was undertaken in 102 patients with idiopathic dilated cardiomyopathy to assess the significance of spontaneous and inducible atrial tachyarrhythmias (ATA). Twenty-six patients were in chronic atrial fibrillation (group I) and 76 patients were in sinus rhythm (group II) 14 patients in group II had a clinical history of ATA or episodes of ATA during Holter monitoring. An electrophysiological study was systematically performed. Programmed atrial stimulation was carried out in group II, and used up to two atrial premature stimuli from the right atrium at 2 cycle lengths (sinus cycle length - 10%, 600 ms) and then one atrial extrastimulus under infusion of 1 to 4 µg. min–1 of isoproterenol. Programmed ventricular stimulation was performed in groups I and II. Sustained atrial iachyarrhythmia (ATA) was induced in 33 patients in group II (42%). isoproterenol infusion facilitated the induction of ATA in only one other patient, who had exercise-related ATA. Eleven patients in group II with spontaneous ATA had inducible sustained ATA. The sensitivity of programmed atrial stimulation to reproduce an ATA was 78.5% and its specificity 64.5%.

Inducible ATA was related to a shorter atrial effective refractory period (209 ± 25 ms vs 228 ± 32. p <0.02). Inducible and spontaneous ATAs were related to older age but not to the existence of spontaneous or inducible ventricular tachycardia; they did not have prognostic significance: the left ventricular ejection fraction and the prognosis were similar in patients with spontaneous or inducible ATA and those without ATA.

In conclusion, the prognosis of idiopathic dilated cardiomyopathy was not affected by the existence of spontaneous or inducible ATA and these arrhyrhmias did not seem to require specific anti-arrhythmic therapy in asymptomatic patients. Programmed a trial stimulation was a useful diagnostic technique to induce an ATA in dilated cardiomyopathy and should be systematically used in patients with tachycardia of unknown origin to elucidate the mechanism of tachycardia.

Key Words: Idiopathic dilated cardiomyopathy • atrial tachycardia • programmed atrial stimulation


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