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European Heart Journal 1992 13(4):531-534;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Cyclosporine in heart transplant recipients: an exercise study of vasopressor effects

J. P. SCOTT, T. W. HIGENBOTTAM, S. LARGE and J. WALLWORK

Transplant Unit, Papworth Hospital Papworth Everard, Cambridge, U.K.

Received 15 March 1990; revised 21 June 1990; .

Correspondence: Dr John P. Scott, Heart-lung Transplant Research Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE

Abstract

The possible vasopressor effect of cyclosporine (CS) on both the systemic and pulmonary vascular beds has been investigated during bicycle exercise in 12 heart transplant recipients (mean age, 41 years) using pulmonary artery catheter measurements. Eight patients were taking cyclosporine and six azathioprine and prednisolone (AzS) as immunosuppressive therapy.

With exercise, CS recipients show a significantly larger rise in systemic pressure than AzS recipients (P<0.001), with persistently higher pulmonary pressures (P <0.001). This suggests a generalized vasopressor effect of CS on the vasculature.

Key Words: Heart transplantation • cyclosporine • azathioprine • steroids • exercise


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