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European Heart Journal 1992 13(4):556-559;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Proto-oncogene expression in rabbit aorta after wall injury First marker of the cellular process leading to restenosis after angioplasty?

C. BAUTERS*, P. DE GROOTE*, M. ADAMANTIDIS{dagger}, C. DELCAYRE{ddagger}, M. HAMON{dagger}, J. M. LABLANCHE*, M. E. BERTRAND*,, B. DUPUIS{dagger} and B. SWYNGHEDAUW{ddagger}

*Service de Cardiologie B, Hópital Cardiologique, 59037 Lille Cedex France
{dagger}Laboratoire de Pharmacologie, Faculté de Medecine, 59045 Lille Cedex France
{ddagger}INSERM U 127, Hópital Lariboisière 75010 Paris, France

Received 31 October 1991; accepted 31 October 1991.

Correspondence: M. E. Bertrand, Service de Cardiologie B, Hópital Cardiologique, boulevard du Pr Lecierc. 59037 Lille Cedex. France

Abstract

In order to study the earliest phenomenons occurring in the arterial wall after balloon angioplasty, the level of expression of the proto-oncogenes, c-fos and c-myc, was studied in rabbit aorta after balloon denudation by using Northern blot analysis. Both c-fos and c-myc are rapidly and transitorily induced (maximal at 30 min and 2 h after mechanical injury for c-fos and c-myc respectively). By comparison, infusion of norepinephrine increases oncogene expression in normal non-denuded rabbit aorta after 1 h, but the combination of both mechanical and hormonal stimuli do not lead to a more important induction than balloon denudation alone.

Key Words: Smooth muscle cell • c-myc • c-fos • proliferation


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