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European Heart Journal 1992 13(6):758-762;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Ischaemic heart disease, skeletal muscle fibres and exercise capacity

J. KARLSSON*,, B. DIAMANT*, K. FOLKERS*, H. ÅSTRÖM{dagger}, S. GUNNES{ddagger}, J. LISKA{ddagger} and B. SEMB{ddagger}

*Department of Clinical Physiology, Karolinska Institute Stockholm
{dagger}Department of Pharmacology, Copenhagen University Copenhagen
{ddagger}Institute for Biomedical Research, The University of Texas at Austin Stockholm
§Departments of Thoracic Clinical Physiology, Karolinska Institute Stockholm
Thoracic Surgery, Karolinska Institute Stockholm

Received 14 November 1990; revised 1 November 1991; .

Correspondence Jan Karlsson, Department of Clinical Physiology, Karolinska Institute, S-I040I Stockholm, Sweden.

Abstract

Twenty-eight male patients with ischaemic heart disease (IHD) performed OBLA (onset of blood lactate accumulation) exercise stress tests and had muscle biopsies taken from their vastus lateralis muscle the day before coronary bypass grafting. All 28 patients showed the same exercise performance pattern as compared to healthy sedentary, age-matched, controls: a low exercise intensity eliciting a blood lactate concentration of 2.0 mmol x 1–1 ( WOBLA), WOBLA corresponded to a high fraction (% WOBLA) of WSL (symptom limited or ‘maximal’ capacity), and a low peak blood lactate concentration. The high % WOBLA and low peak blood lactate indicated a reducedglycogenolytic capacity (‘anaerobic’ performance). Muscle fibre composition disclosed a high mean value of fast twitch (FT), type II or ‘white’ muscle fibres, as compared to sedentary healthy controls. This indicated that this patient group constituted an extreme subgroup of the age-matched population. The distorted muscle fibre composition in IHD could refiect both heredity as well as adaptation to physical inactivity, degenerative cytosolic properties, etc. Muscle and blood contents of a mitochondrial electron trans-locator and nonspecific radical scavenger, ubiquinone or coenzyme Q10(CoQ10), were low, which coincided with an elevated frequency of the fibre subgroup FT(c). The presence of the FT (c) fibre type is assumed to reflect histological uma.

Key Words: Ischaemic heart disease • muscle fibres • exercise capacity • blood lactate concentration • OBLA • ubiquinone • coenzyme Q • vitamin Q • antioxidants • muscle trauma


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