Skip Navigation

European Heart Journal 1992 13(7):960-965;
Copyright © 1992 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by HARGREAVES, A. D.
Right arrow Articles by MUIR, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HARGREAVES, A. D.
Right arrow Articles by MUIR, A. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 The European Society of Cardiology

Haemodynamic responses to glyceryl trinitrate: influence of rate and duration of delivery

A. D. HARGREAVES and A. L. MUIR

Department of Medicine, Royal Infirmary Edinburgh EH3 9YW, U.K

Received 12 March 1991; revised 27 September 1991; .

Correspondence: Dr A D. Hargreaves, Department of Medicine, RoyaJ Infirmary, Edinburgh EH3 9YW.

Abstract

Glyceryl trinitrate (GTN) is known to be a potent venodilator, but the effects might differ depending on the regime of administration. Using a radionuclide blood pool method we examined the changes in peripheral (and pulmonary) venous volume induced by GTN administered in three ways: short (4min) intravenous infusions at 75µg.min–1 (n=7), prolonged intravenous infusion at 50 µg. min–1 (n = 7) or 500 µg sublingual tablet (n=5). Sublingual GTN and the prolonged infusion caused similar decreases in systolic blood pressure (–23±12, –24± 10 mmHg) and increases in calf venous volume (12±4%, 12±5%). For both, the peak effect occurred around 20 min after starting GTN administration (blood pressure 18±12 vs 25±12min, venous volume 21±1 vs 22±7min). Only the prolonged infusion caused a significant fall in diastolic pressure (–14±6mmHg). The short infusion had a similar effect on systolic pressure (–21±16 mmHg) to the other two regimes, but caused a significantly smaller increase in venous volume (6 ±2%), which occurred much earlier (5±2 min). Anterior lung blood volume decreased in response to intravenous GTN and the posterior lung blood volume did not change, suggesting this alteration was secondary to peripheral venodilatation. In conclusion, GTN causes venous dilatation at low levels of delivery with the maximum response occurring after 20 min. In contrast, arterial effects are seen more rapidly and at higher rates of delivery.

Key Words: Glyceryl trinitrate • vasodilator • sublingual and intravenous administration • pulmonary and peripheral venous response • duration of exposure • rate of delivery


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
R. A. Payne, D. Isnardi, P. J. D. Andrews, S. R. J. Maxwell, and D. J. Webb
Similarity between the suprasystolic wideband external pulse wave and the first derivative of the intra-arterial pulse wave
Br. J. Anaesth., November 1, 2007; 99(5): 653 - 661.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. Payne, C. N. Symeonides, D. J. Webb, and S. R. J. Maxwell
Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure
J Appl Physiol, January 1, 2006; 100(1): 136 - 141.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.