Skip Navigation

European Heart Journal 1992 13(7):971-975;
Copyright © 1992 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by FLAPAN, A. D.
Right arrow Articles by EDWARDS, C. R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FLAPAN, A. D.
Right arrow Articles by EDWARDS, C. R. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 The European Society of Cardiology

The relationship between diuretic dose, and the haemodynamic response to captopril in patients with cardiac failure

A. D. FLAPAN, E. DAVIES, B. C. WILLIAMS, T. R. D. SHAW and C. R. W. EDWARDS

Departments of Medicine and Cardiology, Western General Hospital Crewe Road, Edinburgh, Scotland

Received 5 August 1991; revised 11 December 1991; .

Correspondence: Dr A D Flapan, Department of Cardiology, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, Scotland, U.K.

Abstract

The effect of diuretic dose on the haemodynamic response to captopril was assessed in nine patients with chronic cardiac failure. Each patient was given an intravenous dose of captopril while maintained on (a) a low dose diuretic regime, and (b) a high dose diuretic regime. Activity of the renin angiotensin aldosterone system, as assessed by plasma concentrations of these hormones, was greater when patients were receiving the higher dose diuretic regime. The magnitude of haemodynamic response produced by intravenous captopril was greater when the patients were maintained on the high dose diuretic regime, although no significant correlation was found between resting plasma renin activity and resting plasma angiotensin II concentration and the change produced by captopril in any haemodynamic response on either diuretic regime. An increased dosage of loop diuretic potentiates the haemodynamic effects of captopril in patients with cardiac failure. Reduction of diuretic dose prior to introduction of captopril may protect against severe first dose hypotension.

Key Words: Ace inhibitors • haemodynamic response • diuretic dose • RAAS


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
H. P. Brunner-La Rocca, G. Vaddadi, and M. D. Esler
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism
J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1163 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. P. B.-L. Rocca, D. Weilenmann, W. Kiowski, F. E. Maly, and F. Follath
Plasma Levels of Enalaprilat in Chronic Therapy of Heart Failure: Relationship to Adverse Events
J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 565 - 571.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.