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European Heart Journal 1992 13(8):1011-1019;
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Inter-study variability in left ventricular mass measurement Comparison between M-mode echography and MRI

P. GERMAIN*,, G. ROUL*, B. KASTLER{dagger}, J.-M. MOSSARD*, P. BAREISS* and A. SACREZ*

*Cardiologie, Hôpital de Hautepierre 67098 Strasbourg Cedex, France
{dagger}Radiologie I, Hôpital Central 67091 Strasbourg Cedex, France

Received 15 July 1991; revised 15 November 1991; .

Correspondence Philippe Germain, Cardiologie, Hôpital de Hautepierre, 67098 Strasbourg Cedex, France

Abstract

In order to compare variability in M-mode echography and MRI in the assessment of left ventricular mass, 20 echogenic patients without evidence of coronary artery disease were investigated. Two MR and two M-echo examinations were performed within 4 days by different trained operators, each unaware of the other's results. M-mode echo was carried out according to Devereux's method, using the ‘Penn-Cube’ formula. MR protocol included mult islice (8 to 12) true, short-axis spin-echo imaging (10 mm thick with a 1 to 3 mm gap) encompassing the entire left ventricle. Planimetry was manually traced with standardized window settings.

Correlations between both echographic and both MR measurements showed r = 0.89, SEE= 22.7 g and r = 0.96, SEE 11.2g, respectively. Mean inter-study variability was 11 ±6.4% and 6.75±3.8% (P = 0.0021). The threshold value corresponding to the 95 th per centile of the variability data was 21.5% for echography and 13.5% for MR.

In conclusion, MR appeared to be a significantly more reproducible examination tool, when compared with M-mode echo, for the evaluation of left ventricular mass (variability, 63% higher with echo than with MR). The main practical consequence of this result lies in the reduced number of patients required to demonstrate a significant change in the LVM with MR as compared with echography.

Key Words: Left ventricular mass • M-mode echography • magnetic resonance imaging • interstudy variability • reproducibility


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