Skip Navigation

European Heart Journal 1992 13(9):1271-1276;
Copyright © 1992 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by FRIEDEL, N.
Right arrow Articles by HETZER, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FRIEDEL, N.
Right arrow Articles by HETZER, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 The European Society of Cardiology

Haemodynamic effects of different doses of dopexamine hydrochloride in low cardiac output states following cardiac surgery

N. FRIEDEL, R. WENZEL, G. MATHEIS, H. KUPPE, H. BITTNER, S. FILCEK* and R. HETZER

German Heart Institute Berlin 1000 Berlin 65
*Fisons plc Pharmaceutical Division, R &D Laboratories Loughborough, U.K.

Received 9 January 1991; revised 2 December 1991; .

Correspondence: Dr N. Friedel, Deutsches Herzzenlrum Berlin, Augustenburgcr Platz 1, D-1000 Berlin 65, Germany

Abstract

We studied the haemodynamic effects of dopexamine hydrochloride, a ß2-adrenergic agonist with dopaminergic (DA1) activity, in 20 patients with low cardiac output following surgery for coronary artery bypass grafting and/or valve replacement or repair. Following titration of four doses (1, 2, 4 and 6 µg. kg–1. min–1), the dose producing the optimal response was infused for up to 48 h (five patients). During the infusion, significant increases in cardiac index and stroke volume were accompanied by significant decreases in systemic vascular resistance. Heart rate increased significantly up to 6 h and thereafter returned to control levels. Mean blood pressure was reduced but did not fall below 60 mmHg. However, in five patients treated for 48 h mean blood pressure had returned to control levels. Unwanted effects (tachycardia and hypotension) were seen chiefly at higher doses, leading us to conclude that infusion rates of 4 µg . kg–1. min–1 or less will be useful in the treatment of low cardiac output following cardiac surgery.

Key Words: Dopexamine hydrochloride • vasodilator • low cardiac output syndrome • cardiac surgery


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 DTBHome page
Dopexamine after cardiac surgery
DTB, April 1, 1995; 33(4): 30 - 32.
[Abstract] [Full Text] [PDF]

Home page
 DTBHome page
Dopexamine after cardiac surgery
DTB, April 1, 1995; 33(4): 30 - 32.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.