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European Heart Journal 1992 13(Supplement E):80-84; doi:10.1093/eurheartj/13.suppl_E.80
Copyright © 1992 by the European Society of Cardiology.
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© 1992 The European Society of Cardiology

Comparison between preload recruitable stroke work and the end-systolic pressure–volume relationship in man

M. Takeuchi, M. Odake, H. Takaoka, Y. Hayashi and M. Yokoyama

1st Department of Medicine, Kobe University School of Medicine 7-5-1, Kusunoki-cho, Cho-ku, Kobe, 650 Japan

Correspondence: Motoshi Takeuchi, MD, 1st Department of Medicine, Kobe University School of Medicine, 7-5-1, Kusunoki-cho, Chuo-fcu, Kobe, 650 Japan

We compared linearity, inotropic sensitivity (using dobutamine) and afterload dependency (using captopril) of contractile indices derived from the end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW) in man. We investigated 60 patients, 39 with normal (EF ≥ 50%, group 1) and 21 with decreased ventricular function (EF < 50%, group 2). Variably loaded P-V loops were constructed by conductance catheters with vena caval occlusions. The slopes of the ESPVR (Emax and PRSW (Mw) were assessed by linear regression analysis. The correlation coefficients of the ESPVR (r = 0·964) and PRSW (r = 0·976) were both very high, but the Z-value of the ESPVR was lower than for PRSW. During the control period, normalized Emax and Mw were significantly higher in group 1 than group 2 (Emax: 4·l6 ±2·3 vs 2·l8 ±0·l8 mm Hg ml–1 m–2, Mw 109 ±31 vs 86 ±28 103 dyn cm2. After dobutamine, Emax and Mw increased significantly both in group 1 (128% and 124% vs control respectively) and in group 2 (132% and 130% respectively). After captopril, the ESPVR tended to shift to the right with a decrease in afterload; PRSW was unchanged We conclude that PRSW may be a more linear and reliable index for evaluation of contractility in man.

Key Words: Contractility • end-systolic pressure-volume relationship • ventricular function • conductance catheter • Frank-Starling's law


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