Skip Navigation

European Heart Journal 1993 14(1):90-95;
Copyright © 1993 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by TRANCHESI, B.
Right arrow Articles by PILEGGI, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TRANCHESI, B., JR
Right arrow Articles by PILEGGI, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 The European Society of Cardiology

Early administration of captopril and nitroglycerin in combination after acute myocardial infarction: an invasive haemodynamic study

B. TRANCHESI, JR, R. D. SANTOS, B. CARAMELLI, O. GEBARA, V. BARBOSA, G. BELLOTTI and F. PILEGGI

The Heart Institute, University of Sao Paulo Brazil

Received 23 September 1991; revised 5 June 1992; .

Correspondence: Bernardino Tranchesi Jr. Rua Dr Luiz Dib Zogaib, 219, CEP: 05613 — Sao Paulo — Brazil

Abstract

The combination of captopril and nitroglycerin early after acute myocardial infarction (AMI) could lead to a dangerous decrease in blood pressure coronary perfusion. To evaluate the safety aspects and haemodynamic effects of this combination, we studied 36 first ‘Q wave’ thrombolysed anterior wall AMI patients during the 24 h following the onset of symptoms.

Afterwards, thrombolysis patients received a continuous infusion of nitroglycerin and were submitted to pulmonary artery catheterization. Those patients with mean arterial pressure (MAP) ≥ 70 mmHg, cardiac index ≥ 2.21. min–1.m–2, and wedge pressure ≥ 10 mmHg were included and randomized to receive 6.25 mg of captopril every 6 h on the first day and 12.5 mg qid on the second f MAP ≥ 70mmHg (group 1). A second group (group 2) received a placebo. Haemodynamic parameters were determined after 1, 6 and then every 6 h up to 48 h after basal measurements. Significant differences were observed only for the MAP and the rate-pressure product (reduction in group 1 values, P <0.05). However, MAP was maintained within acceptable limits. Our data support the fact that the combination of captopril and nitroglycerin in the early hours of a non-complicated anterior wall AMI is safe, and could guarantee its use in large clinical trials to determine the effects on left ventricle remodelling and survival after AMI.

Key Words: Myocardial infarction • thrombolysis • captopril • nitroglycerin • haemodynamic study


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.