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European Heart Journal 1993 14(10):1334-1343;
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The Europen Society of Cardiology

Evidence of functional alterations in sympathetic activity after myocardial infarction

M. T. SPINNLER*, C. LOMBARDI{dagger},, C. MORETTI*, G. SANDRONE{dagger}, V. PODIO{ddagger}, T. SPANDONARI{ddagger}, J. D. TORZILLO{dagger}, A. BRUSCA* and A. MALLIANI{dagger}

*Divisione di Cardiologia Universitaria, Istituto di Medicina e Chirurgia, Cardiovascolare Italy
{dagger}Medicina Interna II, Osp.L.Sacco, Centro Ricerche Cardiovascolari, CNR, Università di Milano Italy
{ddagger}Servizio di Medicina Nucleare, Istituto di Medicina Internet, Università di Torino Italy

Received 18 January 1993; accepted 12 May 1993.

Correspondence: Prof Federico Lombardi, Medicina Interna II, Ospedale L.Sacco Univ.di Milano, via G. B. Grassi 74, 20157 Milano, Italy.

Abstract

To assess whether the presence of areas of efferent sympathetic denervation might contribute to alterations in sympathetic and vagal neural regulatory activities observed after myocardial infarction, we attempted to correlate the changes in the spectral components ofRR variability with the 1–123 MIBG and Thallium-201 uptake defects. Ten patients with first and uncomplicated myocardial infarction were studied. Thallium-201 and 1–123 MIBG scintigraphy as well as spectral analysis of heart rate variability were performed 7 days, 4, 12 and 30 months after the acute event. Regional abnormalities in 1–123 MIBG uptake were more extensive than the perfusion defects indicated by Thallium-201 images and remained constant throughout the entire period of observation. In the early post-infarction period, spectral analysis of RR variability was characterized by a predominant LF (74±6nu) and a smaller HF (16±3nu) component indicating a sympathetic predominance. Thereafter, we observed a progressive reduction in LF and a gradual increase in HF which were consistent with a normalization of sympatho-vagal balance. These data indicate that after a myocardial infarction, the presence and persistence of areas of sympathetic functional denervation do not seem to play a major role in determining the changes in sympathetic and vagal neural regulatory activities directed to the heart.

Key Words: Sympathetic activation • myocardial infarction • sympathetic efferent denervation • heart rate variability • myocardial scintigraphy


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