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European Heart Journal 1993 14(11):1543-1547;
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Heparin after angioplasty: an unresolved issue?

R. S. MORE, M. J. BRACK and A. H. GERSHLICK

The Academic Department of Cardiology, Glenfield General Hospital Groby Road, Leicester LE3 9QP, U.K.

Received 16 November 1992; revised 4 February 1993; .

Correspondence. Dr A. H. Gershlick, MRCP, The Academic Department of Cardiology, Glenfield General Hospital, Groby Road, Leicester LE3 9QP, U.K.

Abstract

Restenosis following coronary angioplasty remains a signficant problem. Experinental work suggests that appropriate use of heparin may be beneficial through inhibition of smooth muscle cell proliferation. Possible mechanisms of this effect in various models, are discussed. Limited clinical studies to date, however, have failed to show therapeutic efficacy. Possible reasons for this lack of effect are discussed and the importance of assessing heparin in appropriate clinical trials is emphasized.

Key Words: Angioplasty restenosis • heparin


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