Skip Navigation

European Heart Journal 1993 14(3):369-372;
Copyright © 1993 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by CORRAO, S.
Right arrow Articles by LICATA, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CORRAO, S.
Right arrow Articles by LICATA, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 The European Society of Cardiology

Left ventricular diastolic filling alterations in subjects with mitral valve prolapse: a Doppler echocardiographic study

S. CORRAO, R. SCAGLIONE, S. ARNONE and G. LICATA

Department of Internal Medicine, Chair of Medical Pathology, University of Palermo Italy

Received 30 September 1992; .

Correspondence: Salvatore Corrao, c'o Cattedra di Patologia Medica I. Piazza delle Cliniche, 2, 90127 Palermo, Italy

Abstract

To assess left ventricular diastolic filling in mitral valve prolapse (MVP), we studied 22 patients with idiopathic MVP and 22 healthy controls matched for sex, age, body surface area and heart rate. A two-dimensional, M-mode and Doppler echocardiographic examination was performed to exclude any cardiac abnormalities. The two groups had similar diastolic and systolic left ventricular volumes, left ventricle mass and ejection fraction. Doppler measurements of mitral inflow were; E and A areas (the components of the total flow velocity-time integral in the early passive period of ventricular filling, E; and the late active period of atrial emptying, A), the peak E and A velocities (cm. s–1), acceleration and deceleration half-times (ms) of early diastolic rapid inflow, acceleration time of early diastolic flow (AT), total diastolic filling time (DFT) (ms), and the deceleration of early diastolic flow (cm. s–2). From these measurements were calculated: peak A/E ratio (A/E), E area/A area, the early filling fraction, the atrial filling fraction, AT/DFT ratio. All the Doppler measurements reported are the average of three cardiac cycles selected at end expiration. The mean peak A velocity, A/E velocity ratio, deceleration half time and atrial filling fraction were each significantly higher for subjects presenting a MVP (60±12cm. s–1 vs 49±14, P <0.008 98±13% vs 64±12%, P <0.0001; 120±36 ms vs 92±11, P <0.002; 0.45±0.14 vs 0.36±0.08 P <0.02). The opposite was found for the mean deceleration of early diastolic flow, which was significantly lower (290±150cm.s–2 vs 410±122, P <0.007). None of the remaining parameters was significantly different. In conclusion, we have documented a different pattern of ventricular filling in patients with MVP compared to healthy subjects. Other investigations are needed to clarify the significance and the causes of these observations.

Key Words: Diastolic dysfunction • echocardiographic findings • transmitral flow velocity • left ventricular filling.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.