Skip Navigation

European Heart Journal 1993 14(7):910-914;
Copyright © 1993 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PONTREMOLI, R.
Right arrow Articles by PASTORINI, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PONTREMOLI, R.
Right arrow Articles by PASTORINI, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 The European Society of Cardiology

Cardiac diastolic abnormalities and atrial natriuretic factor in essential hypertension

R. PONTREMOLI, G. P. BEZANTE*, C. ROBAUDO, F. MASSARINO, A. SOFIA, G. BERTERO*, G. GNECCO and C. PASTORINI*

Division of Nephrology Italy
*Division of Cardiology, Department of Internal Medicine, University of Genoa Italy

Received 1 June 1992; revised 22 December 1992; .

Correspondence: Roberto Pontremoli, MD, Division of Nephrology, Department of Internal Medicine, viale Benedetto XV, 6. 16132 Genoa, Italy

Abstract

Cardiac function and plasma levels of atrial natriuretic factor (ANF) were studied in a group of 38 patients with untreated essential hypertension and in a group of 31 well matched normotensive controls. ANF was slightly but significantly higher in hypertensives and was directly correlated with mean arterial pressure and inversely with plasma renin activity (PRA). Hypertensives showed normal systolic function and higher cardiac mass compared to controls. ANF was inversely correlated to echocardiographic indexes of left ventricular performance in the former group. At Doppler echocardiographic evaluation, hypertensives showed an impairment in diastolic function which was correlated to the increase in ANF levels. Stepwise multiple regression analysis performed with ANF as the dependent variable and several biohumoral and echocardiographic parameters as the independent variables showed that only cardiac diastolic function and PRA significantly affect ANF levels in hypertensives. In conclusion, an impairment in cardiac diastolic function may be responsible together with other factors for the increased ANF levels encountered in essential hypertension.

Key Words: Atrial natriuretic factor • essential hypertension • cardiac diastolic function


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HeartHome page
G P Bezante, X Chen, G Molinari, A Valbusa, L Deferrari, V Sebastiani, N Yokoyama, S Steinmetz, A Barsotti, and K Q Schwarz
Left ventricular myocardial mass determination by contrast enhanced colour Doppler compared with magnetic resonance imaging
Heart, January 1, 2005; 91(1): 38 - 43.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.