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European Heart Journal 1993 14(7):989-992;
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Dystrophin negative skeletal and myocardial muscle cells in a carrier of Duchenne's muscular dystrophy

K. WATANABE*,, T. IZUMI{dagger}, M. NATSUI*, N. MATSUBARA*, Y. MIYAKITA*, S. KOYAMA*, T. INOMATA*, M. SUZUKI* and A. SHIBATA{dagger}

*Division of Cardiology, Tsubame Rosai Hospital Sawatari 633 Tsubame City, Niigata, 959-12 Japan
{dagger}First Department of Internal Medicine, Niigata University School of Medicine 951 Japan

Received 22 November 1991; revised 18 January 1993; .

Correspondence: K. Watanabe, Division of Cardiology, Tsubame Rosai Hospital. Sawatan 633 Tsubame City, Niigata, 959-12 Japan

Abstract

A 47-year-old woman whose elder son had typical Duchenne's muscular dystrophy (DMD) was diagnosed as the manifesting carrier of the disease. She had developed congestive heart failure but had no evidence of skeletal muscular atrophy. Histological observation of the cardiac muscle revealed a mosaic pattern of dystrophin negative fibres detected by immunofluorescence analysis.

Key Words: Dystrophin • cardiomyopathy • Duchenne's muscular dystrophy


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