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European Heart Journal 1993 14(8):1143-1145;
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The Europen Society of Cardiology

Malignant lymphoma in the donor heart after heart transplantation

P. BURTIN*,, A. GUERCI{dagger}, F. BOMAN{ddagger}, C. DOPFF*, G. PINELLI§, J. P. HABERER* and J. P. VILLEMOT§

*Departement d'anesthésiologie 54500 Vandoeuvre lès Nancy, France
{dagger}Service de médecine A 54500 Vandoeuvre lès Nancy, France
{ddagger}Service d'Anatomopathologie 54500 Vandoeuvre lès Nancy, France
§Service de chirurgie cardiaque et transplantation, Hopital de Brabois 54500 Vandoeuvre lès Nancy, France

Received 5 October 1992; revised 11 February 1993; .

Correspondence. Dr P. Burtin, Assistant en anesthésiologie, Département d'anesthésiologie, Hopital de Brabois, 54500 Vandoeuvre lès Nancy, France

Abstract

A case of post-transplant lymphoproliferative disease (PTLD) with donor heart involvement is reported. The 49-year-old patient presented with heart failure initially ascribed to acute graft rejection. The treatment with high doses of immunosuppressive agents was unsuccessful and the outcome rapidly fatal. This case suggests that cardiac failure occurring after high doses of immunosuppressive therapy could be a sign of early PTLD in heart transplant recipients.

Key Words: Heart transplantation • non-Hodgkin lymphoma • heart neoplasms • congestive heart failure • immunosuppression • immunosuppressive agents


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