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European Heart Journal 1993 14(Supplement A):27-32; doi:10.1093/eurheartj/14.suppl_A.27
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Post-ischaemic cardiac dilatation and remodelling: reperfusion injury of the interstitium

C. Eng, M. Zhao, S. M. Factor and E. H. Sonnenblick

Cardiovascular Research Laboratories and Cardiovascular Center, Division of Cardiology, Albert Einstein College Medicine Bronx, New York, U.S.A.

Correspondence: Calvin Eng, MD. Cardiology Division, VA Medical Center, 130 W. Kingsbridge Rd., Bronx, New York, 10468, U.S.A.

Cardiac size and geometry have an important influence on clinical prognosis in heart disease. The cardiac interstitium would appear to play a major role in modulating muscle configuration after ischaemic insults. Ischaemic reperfusion injury of the heart should not be viewed as confined to the myocyte compartment. There are major events occurring in the interstitial compartment which could ultimately determine the long-term configuration and topography of the heart. Thus, permanent plastic changes in cardiac dimensions appear to evolve after initial alterations in the collagen matrix. The physiological, cellular, biochemical, and molecular considerations in the cardiac interstitium are quite different from those of the myocyte compartment. Accordingly, therapeutic interventions to modulate cardiac geometry and remodelling may differ.

Key Words: Heart enlargement • heart failure • cardiac remodelling • collagen


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