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European Heart Journal 1993 14(Supplement C):2-4; doi:10.1093/eurheartj/14.suppl_C.2
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Vascular remodelling in hypertension

M. J. Mulvany

Danish Biomembrane Research Centre and Institute of Pharmacology, Aarhus University Aarhus, Denmark

Essential hypertension is associated with alterations in the structure of the resistance vasculature, such that the ratio of the media thickness to the lumen diameter (media:lumen ratio) is increased. These abnormalities have previously been explained in terms of vascular growth (an encroachment of the wall into the lumen), but the abnormalities could also be due to a rearrangement of a normal amount of material around a smaller lumen, a process known as ‘remodelling’. This paper reviews briefly some of the evidence for vascular remodelling as an important factor in the pathogenesis of essential hypertension.

Key Words: Vascular remodelling • growth • essential hypertension • resistance arteries


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