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European Heart Journal 1993 14(Supplement D):33-37; doi:10.1093/eurheartj/14.suppl_D.33
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Therapeutic advances in the treatment of left ventricular hypertrophy

T. Natsume

Department of Emergency and Critical Care Medicine, Jichi Medical School Minamikawachi, Tochigi, Japan

Correspondence: Takashi Natsume, MD, Department of Emergency and Critical Care Medicine, Jichi Medical School, 3311–1 Yakushiji, Minamikawachi, Kawachi, Tochigi, Japan.

As a consequence of persistently raised blood pressure, left ventricular hypertrophy (LVH) develops as a compensatory mechanism for wall stress induced by the increase in afterload. Recent advances in the fields of molecular biology and genetics are now clarifying the mechanisms involved in the development of LVH. It has been reported that messenger RNA of oncogenes, such as c-fos and c-myc, increases by stretching; these oncogenes contribute to the progression of LVH, the messenger RNA expression of myosin and contractile protein synthesis in the cardiomyocytes. Vasoactive hormones and vascular contracting factors are also reported to have a progressive effect on LVH. In contrast, some antihypertensive agents have been shown to have pharmacological effects on regression of LVH in animals and man. The mechanisms responsible for LVH progression have been extensively studied. In contrast, the mechanisms of LVH regression have not been defined and require elucidation. This paper outlines the basic recognition of the mechanisms of LVH progression and discusses the varied pharmacological actions of calcium antagonists and angiotensin converting enzyme inhibitors on the regression of LVH in man and rats. Although the role of antihypertensive therapy in regression of LVH remains controversial, the calcium antagonist nicardipine appears to have an important role to play in the treatment of LVH in hypertension and in congestive heart failure.

Key Words: Left ventricular hypertrophy • left ventricular mass • calcium antagonists • nicardipine • angiotensin converting enzyme inhibitors • oncogenes


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