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European Heart Journal 1993 14(Supplement G):12-17; doi:10.1093/eurheartj/14.suppl_G.12
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Chromosomal aberrations and neutrophil activation induced by reperfusion in the ischaemic human heart

J. N. Fabiani*,, B. Farah, A. Vuilleminot, T. Lecompte, I. Emerit, C. Chardigny and A. Carpentier{dagger}

Cardiovascular Surgery Department (Broussais) 96 rue Didot, 75014 Paris, France
* Groupe d'Etude pour la Protection et la Conservation des Organes Hôpital Broussais 96 rue Didot, 75014 Paris, France
{dagger} Laboratoire d'Etude des Greffes et Prothèses Cardiaques 96 rue Didot, 75014 Paris, France

Correspondence: Professor Jean Noë Fabiani, Höpital Broussais, Départment de Chirurgei Cardiovasculaire, 96 rue Didot, 75674 Paris Cedex 14, France

Imperfect myocardial protection during prolonged ischaemia results in adverse changes during reperfusion. Clinical studies carried out during cardiac surgery show that: (1) Oxygen free radicals produced during reperfusion can lead to chromosomal damage in leukocytes. However, this effect seems to be prevented by the addition of allopurinol in the cardioplegic solution. (2) Polymorphonuclear leukocytes are directly implicated in situ in the genesis of free radicals responsible for reperfusion injury. (3) Pre-treatment with trimetazidine, an anti-ischaemic drug with antioxidant properties, and addition of the drug to the cardioplegic solution reduced oxygen free radical damage, as shown by a reduced release of malondialdehyde increase and of myosin; moreover, pre-treatment with trimetazidine enabled patients to undergo surgery with improved left ventricular function.

Key Words: Cardiac surgery • myocardial protection • free redicals • trimetazidine • leukocytes


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