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European Heart Journal 1993 14(Supplement G):2-5; doi:10.1093/eurheartj/14.suppl_G.2
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Metabolic management of ischaemic heart disease

S. L. Chierchia and G. Fragasso

Istituto Scientifico H San Raffaele Milan, Italy

Correspondence: S. L. Chierchia MD, FESC, FACC, Cardiovascular Division, Instituto Scientifico H San Raffaele, Via Olgettina 60, 20132 Milano, Italy

The present review summarizes the available information on the effects of the three major classes of antianginal agents (nitrates, calcium and beta-blockers) on myocardial energy metabolism. It also discusses the role of some new molecules (L-carnitine, trimetazidine and ranolazine) that have been proposed as an alternative pharmacological approach for the metabolic management of cardiac ischaemic syndromes.

Key Words: Ischaemic heart disease • cardiac metabolism • antianginal drugs


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