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European Heart Journal 1993 14(Supplement H):3-13; doi:10.1093/eurheartj/14.suppl_H.3
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Mechanisms and control of repolarization

E. Carmeliet

University of Leuven Leuven, Belgium

Correspondence: Dr. Edward Carmeliet, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium

This paper describes and discusses interventions that may lead to prolongation of the action potential. Special emphasis is given to regulation by drugs. The results of studies focusing on the modulation of inward and outward currents are presented in detail. Specific attention is given to Na+, Ca2+, K+ and Cl channel currents and their components.

Key Words: Action-potential duration • Na+ channel • Ca2+ channel • K+ channel • Cl channel


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