Copyright © 1993 by the European Society of Cardiology.
© 1993 The European Society of Cardiology
Mechanisms and control of repolarization
University of Leuven Leuven, Belgium
Correspondence: Dr. Edward Carmeliet, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
This paper describes and discusses interventions that may lead to prolongation of the action potential. Special emphasis is given to regulation by drugs. The results of studies focusing on the modulation of inward and outward currents are presented in detail. Specific attention is given to Na+, Ca2+, K+ and Cl– channel currents and their components.
Key Words: Action-potential duration Na+ channel Ca2+ channel K+ channel Cl– channel
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
D. Thomas, W. Zhang, K. Wu, A.-B. Wimmer, B. Gut, G. Wendt-Nordahl, S. Kathofer, V. A.W. Kreye, H. A. Katus, W. Schoels, et al. Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein Cardiovasc Res, July 1, 2003; 59(1): 14 - 26. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A Karle and J. Kiehn An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel Cardiovasc Res, January 1, 2002; 53(1): 6 - 8. [Full Text] [PDF] |
||||
![]() |
L. Virag, N. Iost, M. Opincariu, J. Szolnoky, J. Szecsi, G. Bogats, P. Szenohradszky, A. Varro, and J. Gy. Papp The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes Cardiovasc Res, March 1, 2001; 49(4): 790 - 797. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A Karle, V. A.W Kreye, D. Thomas, K. Rockl, S. Kathofer, W. Zhang, and J. Kiehn Antiarrhythmic drug carvedilol inhibits HERG potassium channels Cardiovasc Res, February 1, 2001; 49(2): 361 - 370. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Varro, B. Balati, N. Iost, J. Takacs, L. Virag, D. A Lathrop, L. Csaba, L. Talosi, and J. G. Papp The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization J. Physiol., February 15, 2000; 523(1): 67 - 81. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Ishihara and T. Ehara A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes J. Physiol., August 1, 1998; 510(3): 755 - 771. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Kodama, K. Kamiya, and J. Toyama Cellular electropharmacology of amiodarone Cardiovasc Res, July 1, 1997; 35(1): 13 - 29. [Full Text] [PDF] |
||||

