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European Heart Journal 1993 14(Supplement H):36-40; doi:10.1093/eurheartj/14.suppl_H.36
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Inotropic and haemodynamic effects of d- and d,l-sotalol: Comparison with other antiarrhythmics

L. Seipel and H.-M. Hoffmeister

Department of Cardiology, Medical Hospital University of Tuebingen Germany

Correspondence: Prof Dr med L. Seipel, Abt. inn. Med. III. Med. Universitätsklinik, D-72076 Tuebingen, Germany

The inotropic effects of sotalol in comparison to other antiarrhythmic drugs were tested in an experimental model allowing isovolumic measurements independently of the loading conditions. All class I drugs had a similar negative inotropic effect. d,l-Sotalol caused a dose-dependent depressant effect on the rate of left ventricular pressure development. The same held true for l-sotalol. In contrast, d-sotalol, in clinical doses, revealed no significant inotropic effects in normal hearts. In a postischemic model, d-sotalol led to a further deterioration of left ventricular function. It could be demonstrated by autonomic blockade that this effect was mainly the result of the remaining weak beta-blocking activity of the d-isomer in addition to its class III action. After intravenous administration of amiodarone in doses of 10 mg.kg–1, no significant inotropic effects were found in normal rats.

Key Words: Antiarrhythmic drugs • haemodynamic effects • class III action


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