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European Heart Journal 1993 14(Supplement H):74-77; doi:10.1093/eurheartj/14.suppl_H.74
Copyright © 1993 by the European Society of Cardiology.
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© 1993 The European Society of Cardiology

Effects of sotalol and d-sotalol on ventricular tachycardia and fibrillation induced by programmed electrical stimulation

E. Aliir, N. Sadoul and CH. De Chillou

Service de Cardiologie, Hôpital Central Nancy, France

Correspondence: E. Aliot, Chef. Service de Cardiologie, Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France

It is only in the last few years that the broad-spectrum antiarrhythmic properties of sotalol have become increasingly recognized. Racemic sotalol has potent beta-blocking and class III antiarrhythmic properties, and it has been reported that this drug is able to control supraventricular and ventricular arrhythmias. Recently, several studies performed with the d-sotalol isomer, which is almost devoid of the beta-blocking effects compared to the racemate, suggest significant antiarrhythmic efficacy and good tolerance of the dextro-isomer. In this paper we review and discuss the effects of sotalol and d-sotalol in patients with ventricular tachycardia (VT), ventricular fibrillation (VF) or cardiac arrest in whom VTor VF was induced by programmed electrical stimulation (PES)

Key Words: Sotalol • d-sotalol • ventricular tachycardia • ventricular fibrillation • ventricular arrhythmia • programmed electrical stimulation (PES)


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