Copyright © 1993 by the European Society of Cardiology.
© 1993 The European Society of Cardiology
Antiarrhythmic drugs and torsade de pointes
University of Oklahoma Health Science Center and Department of Veterans Affairs Medical Center Oklahoma, U.S.A.
Correspondence: Ralph Lazzara, MD, University of Oklahorma Health Science Center and Department of Veterans Affairs Medical Center, Department of Medicine, Cardiovascular Section, Post Office Bok 26901, Oklahoma City, Oklahoma 73190, U.S.A.
In the past decade there has been much progress in understanding the clinical features and associations of drug-induced long QT syndromes, their inter-relationships with other long QT syndromes, and electrophysiological mechanisms that may be in volved in the development oftorsade de pointes, the major proarrhythmic correlate of prolonged repolarization. The most likely electrophysiologic basis for torsade de pointes is the development of after-depolarizations facilitated by hypokalemia, bradycardia and lengthened QT intervals. Torsade de pointes can be produced by all antiarrhythmic agents that lengthen repolarization, although the precise incidence varies with different agents and is not quantitatively related to the degree of QT prolongation. Quinidine, disopyramide and procainamide (with its metabolite N-acetyl procainamide) are strongly concordant in the production oftorsade de pointes. Such concordance suggests that there is an individual predisposition to the induction of early after-depolarizations (EAD) with exposure to agents that prolong repolarization. However, concordance with agents of other classes, such as sotalol, is less certain, and amiodarone appears to be discordant. The discordance between potency in prolonging the QT interval and the proclivity to induce torsade de pointes may hold the key to separating the salutary therapeutic antiarrhythmic effects from adverse proarrhythmic effects of class III agents. There is an optimistic perception that the development of new agents that potently prolong repolarization will give a modern realization of the old concept that prolongation of refractoriness is a uniquely powerful anti-re-entrant, antitachyarrhythmic action.
Key Words: Torsade de pointes • antiarrhythmic drugs • long QT syndrome • early after-depolarizations
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