Copyright © 1994 by the European Society of Cardiology.
© 1994 The European Society of Cardiology
Peak oxygen uptake during exercise in mitral stenosis with sinus rhythm or atrial fibrillation: lack of correlation with valve area
A study in 70 patients
*Service de Cardiologie Hôspital Beaujon, Clichy
Service de Cardiologie Hospital Saint Joseph, Lyon, France
Received 15 March 1993; revised 23 July 1993; .
Correspondence: Dr Alain Cohen-Solal, Service de Cardiologic, Hopital Beaujon, 10 Boulevard du General Lexkrc, 92110, Clichy, France
Abstract
Although the haemodynamic response during submaximal supine exercise in mitral stenosis has been well described, the determinants of peak oxygen uptake during maximal upright exercise are poorly characterized and may differ in sinus rhythm and atrial fibrillation. Seventy patients with isolated mitral stenosis underwent Doppler-echocardiography and bicycle exercise with respiratory gas analysis. Forty-two patients were in sinus rhythm (Group I) and 28 in atrial fibrillation (Group II). Peak oxygen uptake it was 21·3±5·6 ml. min–1 kg–1 in group I and 18·1 ± 5·1 ml min–1 kg–1 in group II (P<0·05). There was no significant correlation between indices of exercise tolerance (exercise duration, ventilatory threshold, peak oxygen uptake, indexed peak oxygen uptake, peak oxygen pulse) and valve area or gradient in either group. Indexed peak oxygen uptake was not correlated to 
oxygen pulse but was linearly related (r=0·43) to heart rate ( heart rate =peak heart rate=rest heart rate) in Group I but not in Group II. Thus, in patients with mitral stenosis, no correlation was found between the mitral valve area or the gradient at rest and maximal upright exercise tolerance, suggesting that peripheral adaptation and, in sinus rhythm, chronotropic reserve, are important compensatory mechanisms.
Key Words: Peak oxygen uptake • mitral stenosis • exercise testing
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Matt, T. Carrel, M. White, I. Lefkovits, and J. Van Eyk Proteomics in cardiovascular surgery J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 210 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. McGregor and M. J. Dunn Proteomics of the Heart: Unraveling Disease Circ. Res., February 17, 2006; 98(3): 309 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Casey, P. G. Arthur, and M. A. Bogoyevitch Proteomic Analysis Reveals Different Protein Changes during Endothelin-1- or Leukemic Inhibitory Factor-induced Hypertrophy of Cardiomyocytes in Vitro Mol. Cell. Proteomics, May 1, 2005; 4(5): 651 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Podgoreanu and D. A. Schwinn Genomics and the circulation Br. J. Anaesth., July 1, 2004; 93(1): 140 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Nair, A. Jaleel, Y. W. Asmann, K. R. Short, and S. Raghavakaimal Proteomic research: potential opportunities for clinical and physiological investigators Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E863 - E874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Yuda, S Nakatani, Y Kosakai, T Satoh, Y Goto, M Yamagishi, K Bando, S Kitamura, and K Miyatake Mechanism of improvement in exercise capacity after the maze procedure combined with mitral valve surgery Heart, January 1, 2004; 90(1): 64 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. McGregor and M. J. Dunn Proteomics of heart disease Hum. Mol. Genet., October 15, 2003; 12(90002): R135 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Langerveld, N. M. van Hemel, J. C. Kelder, J. M. P. G. Ernst, H. W. M. Plokker, and W. Jaarsma Long-term follow-up of cardiac rhythm after percutaneous mitral balloon valvotomy: Does atrial fibrillation persist? Europace, January 1, 2003; 5(1): 47 - 53. [Abstract] [PDF]
|
|